There have been numerous studies of prevalence of CPS serotypes in the developed world, but few studies from developing countries where the disease incidence is higher.
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A CPS conjugate vaccine approach against this pathogen is intriguing, but several questions need to be addressed, including the valency of CPS types required for an effective vaccine.
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However, perhaps the most compelling evidence for a role in pathogenesis are data that CPS conjugate vaccines protect against diarrheal disease in non-human primates. jejuni disease has not been well defined beyond descriptive studies demonstrating a role in serum resistance and for diarrhea in a ferret model of disease. Although capsules are virulence factors for other pathogens, the role of CPS in C. Both CPS expression and expression of modifications are subject to phase variation by slip strand mismatch repair. This structural diversity is consistent with CPS being the major serodeterminant of the Penner scheme, of which there are 47 C. These capsular polysaccharides vary in sugar composition and linkage, especially those involving heptoses of unusual configuration and O-methyl phosphoramidate linkages. jejuni is unusual for an intestinal pathogen in its ability to coat its surface with a polysaccharide capsule (CPS). 2 Department of Chemistry, University of Guelph, Guelph, ON, CanadaĬampylobacter jejuni remains a major cause of bacterial diarrhea worldwide and is associated with numerous sequelae, including Guillain Barré Syndrome, inflammatory bowel disease, reactive arthritis, and irritable bowel syndrome.
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1 Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA.